Denver and Los Angeles clash in a pivotal AFC West showdown, as Herbert and a deeper Chargers offense look to press for an early division lead while Denver seeks a bounce-back against a high-powered unit. Khalil Mack’s IR stint forces a shift in the edge rotation and tests Denver’s protection and run schemes, making every possession critical.

Key matchups shape fantasy angles: Bonito vs Alt on the edge, Bo Nix’s legs against a mobile Chargers defense, and Keenan Allen with Johnston testing Denver’s secondary. The game could hinge on red-zone success, turnover margins, and how well Denver balances blitz looks with zone coverage.

Titans host the Rams in Nashville as Cam Ward’s NFL debut sparks guarded optimism. Tennessee slides into a run-first game plan while Ward shows measured progression, hitting tight ends and quick throws to keep the offense afloat. The defense forces turnovers and the special teams provide spark, but lingering concerns about protection and play-calling linger ahead of Week 2. A competitive home win would validate Ward’s upside and give fantasy managers a clearer read on Titans pass-catchers and the backfield.

Gunner Helm and Chig Okonkwo remain central to the short-to-intermediate game, with Van Jefferson offering a usable floor in single-coverage looks. If play-action and tempo tick up, more targets could flow to Helm, Okonkwo, and Riley Moss’ Broncos-adjacent matchup could hint at development for the Titans’ receiving corps. The show remains optimistic that improvement under Callahan can translate into reliable fantasy points as the Titans attempt a breakthrough at home.